[Trends in the eradication rates of Helicobacter pylori infection in Daegu and Gyeongsangbuk-do, Korea: multicenter study over 13 years].

Title
[Trends in the eradication rates of Helicobacter pylori infection in Daegu and Gyeongsangbuk-do, Korea: multicenter study over 13 years].
Author(s)
이시형정연수[정연수]박찬서[박찬서]오명진[오명진]김경옥장병익전성우[전성우]정민규[정민규]박경식[박경식]김은수[김은수]
Keywords
amoxicillin; antiinfective agent; clarithromycin; esomeprazole; omeprazole; proton pump inhibitor; rabeprazole; adult; aged; article; disease eradication; drug administration; drug combination; female; gastrointestinal endoscopy; Helicobacter infection; Helicobacter pylori; human; male; middle aged; multicenter study; pathology; retrospective study; South Korea; statistical model; treatment outcome; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Disease Eradication; Drug Administration Schedule; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Esomeprazole; Female; Helicobacter Infections; Helicobacter pylori; Humans; Logistic Models; Male; Middle Aged; Omeprazole; Proton Pump Inhibitors; Rabeprazole; Republic of Korea; Retrospective Studies; Treatment Outcome
Issue Date
201402
Citation
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.63, no.2, pp.82 - 89
Abstract
The eradication rates of Helicobacter pylori infection have been reported to have decreased over the years due to antibiotics resistance. The aim of this study is to investigate the trend of eradication rates of first-line triple therapy for H. pylori over the past 13 year period, and to evaluate factors affecting H. pylori eradication in Daegu and Gyeongsangbuk-do, Korea. A total of 2,982 patients with H. pylori infection who were treated with either 1 week or 2 weeks first-line therapy (proton pump inhibitor [PPI], amoxicillin, and clarithromycin) from January 1999 through December 2011 were included in this study. Data were collected by retrospectively reviewing the medical records. The overall H. pylori eradication rate was 87.2%. The eradication rates from 1999 to 2011 fluctuated between 78.0% and 95.7%, but no definite evidence of a decreasing tendency was seen over the 13 year period (p=0.113). Furthermore, there was no significant difference in the eradication rate according to the duration of therapy (p=0.592). However, there was a significant difference in the eradication rate among various PPIs (p<0.01). There was no decreasing trend in the H. pylori eradication rate over the past 13 years in Daegu and Gyeongsangbuk-do, Korea. There also was no difference in the eradication rates depending on duration of therapy. However, a significant difference was noted among various PPIs.
URI
http://hdl.handle.net/YU.REPOSITORY/32986http://dx.doi.org/10.4166/kjg.2014.63.2.82
ISSN
1598-9992
Appears in Collections:
의과대학 > 내과학교실 > Articles
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