Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin

Title
Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin
Author(s)
정태천강미정고규섭오도경김진성Keumhan Noh[Keumhan Noh]강원구Won Ki Yoon[Won Ki Yoon]Hyoung Chin Kim[Hyoung Chin Kim]Hye Gwang Jeong[Hye Gwang Jeong]
Keywords
GERM-FREE RATS; MASS-SPECTROMETRY; INDUCED TOXICITY; IN-VITRO; MICROFLORA; WOGONIN; PLASMA; BIOTRANSFORMATION; HESPERIDIN; RADIX
Issue Date
201403
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.37, no.3, pp.371 - 378
Abstract
Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: C-max, T-1/2(beta), K-el and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin.
URI
http://hdl.handle.net/YU.REPOSITORY/32963http://dx.doi.org/10.1007/s12272-013-0179-2
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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