Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents

Title
Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents
Author(s)
이재민박미림[박미림]이영호[이영호]강혜령[강혜령]이지원[이지원]강형진[강형진]박경덕[박경덕]신희영[신희영]안효섭[안효섭]백희조[백희조]국훈[국훈]황태주[황태주]이재욱[이재욱]정낙균[정낙균]조빈[조빈]김학기[김학기]이수현[이수현]구홍회[구홍회]유건희[유건희]성기웅[성기웅]고경남[고경남]임호준[임호준]서종진[서종진]박준은[박준은]임연정[임연정]유철주[유철주]하정옥
Keywords
SEVERE APLASTIC-ANEMIA; STEM-CELL TRANSPLANTATION; TOTAL-BODY IRRADIATION; ANTI-THYMOCYTE GLOBULIN; VERSUS-HOST-DISEASE; MARROW-TRANSPLANTATION; FANCONI-ANEMIA; BONE-MARROW; PEDIATRIC-PATIENTS; ANTITHYMOCYTE GLOBULIN
Issue Date
201403
Publisher
WILEY-BLACKWELL
Citation
PEDIATRIC TRANSPLANTATION, v.18, no.2, pp.221 - 229
Abstract
This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n=24), iBMFS, (n=16), and primary immune deficiency/inherited metabolic disorder (n=25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II-IV graft-versus-host disease was 32.3%. At a median follow-up of 71months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91x10(5)/kg of infused CD34+ cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p=0.04) and OS (p=0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/32886http://dx.doi.org/10.1111/petr.12213
ISSN
1397-3142
Appears in Collections:
의과대학 > 소아청소년과학교실 > Articles
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