Effect of Statin Treatment in Patients With Acute Myocardial Infarction and Left Ventricular Systolic Dysfunction According to the Level of High-Sensitivity C-Reactive Protein

Title
Effect of Statin Treatment in Patients With Acute Myocardial Infarction and Left Ventricular Systolic Dysfunction According to the Level of High-Sensitivity C-Reactive Protein
Author(s)
김영조정해창[정해창]안영근[안영근]박근호[박근호]심두선[심두선]홍영준[홍영준]김주한[김주한]정명호[정명호]채승철[채승철]조명찬[조명찬]
Keywords
CHRONIC HEART-FAILURE; PERCUTANEOUS CORONARY INTERVENTION; TRIAL EVALUATING ROSUVASTATIN; JUPITER JUSTIFICATION; INFLAMMATION; THERAPY; CARDIOMYOPATHY; CHOLESTEROL; PREVENTION; INSIGHTS
Issue Date
201403
Publisher
INT HEART JOURNAL ASSOC
Citation
INTERNATIONAL HEART JOURNAL, v.55, no.2, pp.106 - 112
Abstract
The effects of statins on the prognosis of patients with left ventricular (LV) systolic dysfunction remain controversial. The aim of this study was to assess the effect of statin treatment on clinical outcomes in acute myocardial infarction (AMI) patients with LV systolic dysfunction. A total of 5,119 AMI patients with LV ejection fraction less than 50% on the initial echocardiogram were analyzed in the Korean Acute Myocardial Infarction Registry. The study population was divided into 4 groups according to the level of high sensitivity C-reactive protein (hs-CRP) and statin treatment: low hs-CRP (hs-CRP <= 2.0 mg/L) and high hs-CRP (hs-CRP > 2 mg/L) with or without statin therapy. We evaluated the incidence of major adverse cardiac events (MACEs) including cardiac death, reinfarction, target lesion revascularization, and coronary artery bypass grafting during a 12-month period in each group. Stalin therapy did not significantly prevent the MACEs in the low hs-CRP groups (with statin 10.1% versus without statin: 12.0%, P = 0.249). In the high hs-CRP groups, however, the incidence of MACEs was significantly decreased with statin treatment (with statin: 11.3%, without statin: 20.8%, P < 0.001). These findings were consistently observed in all subgroups of the high-hs CRP group, including the subgroup with an LV ejection fraction less than 40%. In a multivariable logistic regression analysis of the high hs-CRP group, lack of statin therapy was a significant predictor of MACE incidence (odds ratio: 1.573, 95% confidence interval: 1.079-2.293, P = 0.018). The statin treatment was associated with better outcome in AMI and LV dysfunction patients with hs-CRP >= 2 mg/dL.
URI
http://hdl.handle.net/YU.REPOSITORY/32871
ISSN
1349-2365
Appears in Collections:
의과대학 > 내과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE