Whole blood versus serum ionized calcium concentrations in dialysis patients

Title
Whole blood versus serum ionized calcium concentrations in dialysis patients
Author(s)
도준영강석휘조규향박종원윤경우
Keywords
MINERAL METABOLISM; HEMODIALYSIS
Issue Date
201403
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v.29, no.2, pp.226 - 230
Abstract
Background/Aims: The aim of this study is to measure the difference of ionized calcium between heparinized whole blood and serum. Methods: We recruited 107 maintenance hemodialysis (HD) patients from our hospital HD unit. The clinical and laboratory data included ionized calcium in serum and in whole blood (reference, 4.07 to 5.17 mg/dL). Results: The level of ionized calcium in serum was higher than that in whole blood (p < 0.001). Bland-Altman analysis showed that difference for ionized calcium was 0.5027. For the difference, the nonstandardized p was -0.4389 (p < 0.0o1) and the intercept was 2.2418 (p < 0.001). There was a significant difference in the distribution of categories of ionized calcium level between two methods (lc, 0.279; p < 0.001). Conclusions: This study demonstrates that whole blood ionized calcium is underestimated compared with serum ionized calcium. Positive difference increases as whole blood ionized calcium decreases. Therefore, significant hypocalcemia in whole blood ionized calcium should be verified by serum ionized calcium.
URI
http://hdl.handle.net/YU.REPOSITORY/32858http://dx.doi.org/10.3904/kjim.2014.29.2.226
ISSN
1226-3303
Appears in Collections:
의과대학 > 내과학교실 > Articles
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