Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli 0157:H7 and Staphylococcus aureus biofilm formation

Title
Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli 0157:H7 and Staphylococcus aureus biofilm formation
Author(s)
이진태조무환이진형김용규유시용[유시용]
Keywords
PSEUDOMONAS-AERUGINOSA; LISTERIA-MONOCYTOGENES; ENCAPSULATED EUGENOL; MASS-SPECTROMETRY; STAINLESS-STEEL; O157H7 BIOFILM; O157/H7; O157-H7; FLAGELLA; MOTILITY
Issue Date
201403
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, v.174, pp.47 - 55
Abstract
Infection by enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a worldwide problem, and there is no effective therapy. Biofilm formation is closely related to EHEC infection and is also a mechanism of antimicrobial resistance. Antibiofilm screening of 560 purified phytochemicals against EHEC showed that ginkgolic acids C15:1 and C17:1 at 5 mu g/ml and Ginkgo biloba extract at 100 mu g/ml significantly inhibited EHEC biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. Importantly, at their working concentrations, ginkgolic acids and G. biloba extract did not affect bacterial growth. Transcriptional analyses slimed that ginkgolic acid C15:1 repressed curli genes and prophage genes in EHEC, and these findings were in-line with reduced fimbriae production and biofilm reductions. Interestingly, ginkgolic acids and G. biloba extract did not inhibit the biofilm formation of a commensal E. coli K-12 strain. In addition, ginkgolic acids and G. biloba extract inhibited the biofilm formation of three Staphylococcus aureus strains. The findings of this study suggest that plant secondary metabolites represent an important resource for biofilm inhibitors. (C) 2014 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/32853http://dx.doi.org/10.1016/j.ijfoodmicro.2013.12.030
ISSN
0168-1605
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공과대학 > 화학공학부 > Articles
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