Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma

Title
Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma
Author(s)
구미진최준혁
Keywords
E-CADHERIN; BETA-CATENIN; ABERRANT EXPRESSION; TUMOR PROGRESSION; GASTRIC-CANCER; CELL CARCINOMA; VIMENTIN; INVASION; FIBRONECTIN; METASTASIS
Issue Date
201403
Publisher
BMJ PUBLISHING GROUP
Citation
JOURNAL OF CLINICAL PATHOLOGY, v.67, no.3
Abstract
Background The aim of this study was to evaluate the epithelial-mesenchymal transition (EMT) and to assess its prognostic significance in intrahepatic cholangiocarcinoma. Methods We performed immunohistochemical stainings for E-cadherin, beta-catenin, vimentin and fibronectin in a total of 85 cases. Results Expression of vimentin and reduced expression of E-cadherin were found to show correlation with poor differentiation (p=0.017, p=0.010). Reduced expression of beta-catenin showed significant association with poor differentiation (p=0.023), tumour size (p=0.028) and lymph node metastasis (p=0.011). According to the expression pattern of E-cadherin, beta-catenin, vimentin and fibronectin we categorised four phenotypes: complete type, hybrid type, null type and wild type. The complete type of beta-catenin with vimentin or fibronectin was found to show an association with lymph node metastasis (p=0.048, p=0.012). Significantly worse overall survival (OS) and disease-free survival (DFS) was observed for the complete type, and the best OS and DFS were observed for the wild type. Conclusions EMT phenotypes can be useful markers for prediction of patient outcomes.
URI
http://hdl.handle.net/YU.REPOSITORY/32848http://dx.doi.org/10.1136/jclinpath-2013-201806
ISSN
0021-9746
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의과대학 > 병리학교실 > Articles
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