CuO nanosheets-enhanced flow-injection chemiluminescence system for determination of vancomycin in water, pharmaceutical and human serum

Title
CuO nanosheets-enhanced flow-injection chemiluminescence system for determination of vancomycin in water, pharmaceutical and human serum
Author(s)
주상우A. Hasanzadeh[ A. Hasanzadeh]M. Iranifam[M. Iranifam]M. Fathinia[ M. Fathinia]요네스피로즈살라리알리레자카타이
Keywords
PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; HUMAN PLASMA; LUMINOL CHEMILUMINESCENCE; GLYCOPEPTIDE ANTIBIOTICS; GOLD NANOPARTICLES; SPECTROPHOTOMETRIC DETERMINATION; HYDRAZINE CHEMILUMINESCENCE; CAPILLARY-ELECTROPHORESIS; POTASSIUM-PERMANGANATE
Issue Date
201403
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v.122, pp.737 - 743
Abstract
A novel, rapid and sensitive CuO nanosheets (NSs) amplified flow-injection chemiluminescence (CL) system, luminol-H2O2-CuO nanosheets, was developed for determination of the vancomycin hydrochloride for the first time. It was found that vancomycin could efficiently inhibit the CL intensity of luminol-H2O2-CuO nanosheets system in alkaline medium. Under the optimum conditions, the inhibited CL intensity was linearly proportional to the concentration of vancomycin over the ranges of 0.5-18.0 and 18.0-40.0 mg L-1, with a detection limit (3 sigma) of 0.1 mg L-1. The precision was calculated by analyzing samples containing 5.0 mg L-1 vancomycin (n = 11) and the relative standard deviation (RSD) was 2.8%. Also, a high injection throughput of 120 sample h(-1) was obtained. The CuO nanosheets were synthesized by a sonochemical method. Also, X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses were employed to characterize the CuO nanosheets. The method was successfully employed to determine vancomycin hydrochloride in environmental water samples, pharmaceutical formulation and spiked human serum. (C) 2013 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/32829http://dx.doi.org/10.1016/j.saa.2013.12.014
ISSN
1386-1425
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공과대학 > 기계공학부 > Articles
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