Clinical course of patients with aspirin-exacerbated respiratory disease: can we predict the prognosis?

Title
Clinical course of patients with aspirin-exacerbated respiratory disease: can we predict the prognosis?
Author(s)
진현정김주희[김주희]최길순[최길순]김정은[김정은]예영민[예영민]김승현[김승현]박해심[박해심]
Keywords
LEUKOTRIENE RECEPTOR ANTAGONIST; INTOLERANT ASTHMA; GENETIC-POLYMORPHISM; PROVOCATION TESTS; NATURAL-HISTORY; NASAL POLYPS; ASSOCIATION; HYPERSENSITIVITY; RHINOSINUSITIS; SENSITIVITY
Issue Date
201403
Publisher
FUTURE MEDICINE LTD
Citation
PHARMACOGENOMICS, v.15, no.4, pp.449 - 457
Abstract
Aim: This study aimed to identify prognostic factors of aspirin-exacerbated respiratory disease by comparing clinical and genetic data with the clinical course. Patients & methods: Patients were classified into two groups according to their response to inhalation rechallenge with lysine-aspirin after at least 1 year of regular treatment with antiasthmatic medications. Results: Forty eight patients (39.3%, group I) had negative responses, whereas 74 patients (60.7%, group II) had positive responses (n = 23) or were not rechallenged owing to persistent symptoms (n = 51). FEV1 at diagnosis and follow-up were significantly lower in group II than in group I. The CCR3 polymorphism at -520T/G differed significantly between the two groups, whereas no difference was found in other SNPs. Conclusion: Baseline FEV1 and lower lung function after treatment were clinical factors indicating a poor prognosis of aspirin-exacerbated respiratory disease. The G allele of CCR3 -520T > G was associated with persistent bronchial hypersensitivity to aspirin.
URI
http://hdl.handle.net/YU.REPOSITORY/32823http://dx.doi.org/10.2217/pgs.14.2
ISSN
1462-2416
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의과대학 > 내과학교실 > Articles
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