Comparisons of Everolimus and Paclitaxel-Eluting Stents in Patients with Acute Myocardial Infarction

Title
Comparisons of Everolimus and Paclitaxel-Eluting Stents in Patients with Acute Myocardial Infarction
Author(s)
김영조SEUNG-WOON RHA[SEUNG-WOON RHA]SEUNG HO HUR[SEUNG HO HUR]KANG-YIN CHEN[KANG-YIN CHEN]YONG-JIAN LI[YONG-JIAN LI]DONG JOO OH[DONG JOO OH]MYUNG HO JEONG[MYUNG HO JEONG]JANG HO BAE[JANG HO BAE]TAE HOON AHN[TAE HOON AHN]GUANG-PING LI[GUANG-PING LI]
Keywords
CORONARY-ARTERY-DISEASE; RANDOMIZED-TRIALS; CLINICAL-EVALUATION; SPIRIT III; FOLLOW-UP; METAANALYSIS; THROMBOSIS; POLYMER; REVASCULARIZATION; INTERVENTION
Issue Date
201504
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF INTERVENTIONAL CARDIOLOGY, v.28, no.2, pp.147 - 156
Abstract
BackgroundIt has been established that the newer-generation drug-eluting stent (DES) everolimus-eluting stent (EES) is superior to the first-generation DES paclitaxel-eluting stent (PES). However, the advantages of EES over PES in the setting of acute myocardial infarction (AMI) need to be fully elucidated. MethodsThe present analysis enrolled 2,911 AMI patients receiving PES (n=1,210) or EES (n=1,701) in a large-scale, prospective, multicenter Korea Acute Myocardial Infarction Registry (KAMIR). Propensity score matching was used to adjust for baseline biases in clinical and angiographic characteristics, yielding a total of 2,398 patients (1,199 receiving PES and 1,199 receiving EES). Various clinical outcomes at 1 year were compared between the two propensity score matched groups. Target lesion failure (TLF) was defined as the composite of cardiac death, recurrent nonfatal myocardial infarction (Re-MI), or target lesion revascularization (TLR). ResultsBaseline clinical and angiographic characteristics were comparable between the two groups after propensity score matching. Clinical outcomes of the propensity score matched patients showed that the rates of in-hospital and 1-year cardiac and all-cause death were similar between the two groups. But patients in the EES group had significantly lower incidences of Re-MI (1.4% vs 2.8%, P=0.002), TLR (1.2% vs 3.1%, P=0.001), TLF (6.4% vs 10.2%, P=0.001), and probable or definite stent thrombosis (0.3% vs 1.8%, P<0.001) than did those in the PES group. ConclusionsThe present propensity matched analysis suggests that the use of EES in the setting of AMI appears to be superior to PES in reducing TLF, and stent thrombosis.
URI
http://hdl.handle.net/YU.REPOSITORY/32809http://dx.doi.org/10.1111/joic.12187
ISSN
0896-4327
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의과대학 > 내과학교실 > Articles
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