In vitro analysis of the complete CIDE domain interactions of the Drep system in fly

Title
In vitro analysis of the complete CIDE domain interactions of the Drep system in fly
Author(s)
박현호이승미
Keywords
CASPASE-ACTIVATED DNASE; DROSOPHILA-MELANOGASTER; FRAGMENTATION SYSTEM; CHAPERONE ACTIVITY; CRYSTAL-STRUCTURE; APOPTOSIS; ICAD; INHIBITOR; PROTEIN; DFF40
Issue Date
201403
Publisher
SPRINGER
Citation
APOPTOSIS, v.19, no.3, pp.428 - 435
Abstract
CIDE domain containing proteins are involved in apoptosis and lipid metabolism, and four CIDE containing proteins, Drep1, Drep2, Drep3, and Drep4, have been identified in fly. In this study, we found that Drep3 interacts with Drep4 via the CIDE domain specifically, which completes the interaction map of Drep system in fly, cyclic interactions: Drep1-Drep2-Drep3-Drep4-Drep1. In addition, we analyzed the dynamic stoichiometry changes of Drep proteins upon binding to their binding partners. Our current studies will help us to understand Drep system in fly as well as CIDE domain for protein-protein interactions.
URI
http://hdl.handle.net/YU.REPOSITORY/32790http://dx.doi.org/10.1007/s10495-013-0941-4
ISSN
1360-8185
Appears in Collections:
이과대학 > 화학생화학부 > Articles
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