Anti-allergic Inflammatory Activities of Compounds of Amomi Fructus

Title
Anti-allergic Inflammatory Activities of Compounds of Amomi Fructus
Author(s)
최혁재최현규[최현규]제인규[제인규]김금진김상현[김상현]김정아[김정아]이승호
Keywords
CYTOKINE PRODUCTION; HISTAMINE-RELEASE; GALLIC ACID
Issue Date
201504
Publisher
NATURAL PRODUCTS INC
Citation
NATURAL PRODUCT COMMUNICATIONS, v.10, no.4, pp.631 - 632
Abstract
Activity-guided isolation of compounds from the fruits of Amomztm xanthioides resulted in the purification of fourteen phenolic compounds, 4-hydroxybenzaldehyde (1), 3,4-dihydroxybenzaldehyde (2), 3,5-dimethoxy-4-methylbenzaldehyde (3), syringic aldehyde (4), benzoic acid (5), 3,4-dihydroxy benzoic acid (6), vanillic acid (7), 3-hydroxy-2-methoxybenzoic acid (8), o-vanillic acid (9), phenylacetic acid (10), tyrosol (11), pyrocatechol (12), 1,2,4,5-tetramethoxybenzene (13), and 3,3',5,5'-tetramethoxybipheny1-4,4'-diol (14). To evaluate the anti-allergic inflammatory activities of these compounds, we examined the inhibitory effects of the isolates (1-14) on histamine release and on the expressions of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 genes by using human mast cells. Of the tested compounds, 9, 11, and 13 suppressed histamine release from mast cells, and all isolates attenuated the expressions of the pro-inflammatory cytokines, TNF-alpha and IL-6 genes in human mast cells.
URI
http://hdl.handle.net/YU.REPOSITORY/32749
ISSN
1934-578X
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약학대학 > 약학부 > Articles
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