Synthesis of hydroxylated tryptanthrins as possible metabolites and characterization

Title
Synthesis of hydroxylated tryptanthrins as possible metabolites and characterization
Author(s)
장영동김동현모이눌카림로양
Keywords
TANDEM MASS-SPECTROMETRY; RAT-LIVER MICROSOMES; ISATIS-TINCTORIA; IDENTIFICATION; RUTAECARPINE; INDUCTION; PRINCIPLE; ANALOGS; AGENTS
Issue Date
201504
Publisher
WALTER DE GRUYTER GMBH
Citation
HETEROCYCLIC COMMUNICATIONS, v.21, no.2, pp.67 - 71
Abstract
A series of dihydroxytryptanthrins was prepared by the reaction of a suitably substituted isatoic anhydride and isatin as possible metabolites of tryptanthrin. A high-performance liquid chromatography analysis of the synthetic compounds confirmed that 8,9-dihydroxytryptanthrin is the metabolite isolated from rat liver cytosolic metabolites. Although tryptanthrin shows strong cytotoxicity against human cancer cell lines, none of the hydroxylated tryptanthrins exhibit any significant cytotoxicity against selected human cancer cell lines up to 50 mu m.
URI
http://hdl.handle.net/YU.REPOSITORY/32734http://dx.doi.org/10.1515/hc-2014-0103
ISSN
0793-0283
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약학대학 > 약학부 > Articles
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