Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects

Title
Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
Author(s)
김석영임현창[임현창]송경호[송경호]유훈[유훈]이정석[이정석]정의원[정의원]최성호[최성호]
Keywords
BMP-INDUCED OSTEOGENESIS; POROUS HYDROXYAPATITE; AUGMENTATION TECHNIQUES; GRAFT SUBSTITUTES; PORE-SIZE; REGENERATION; POROSITY; INGROWTH; MACROPOROSITY; PLACEMENT
Issue Date
201504
Publisher
KOREAN ACAD PERIODONTOLOGY
Citation
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, v.45, no.2, pp.46 - 55
Abstract
Purpose: This study evaluated the mechanical and structural properties of biphasic calcium phosphate (BCP) blocks processed using a modified extrusion method, and assessed their in vivo effectiveness using a rabbit calvarial defect model. Methods: BCP blocks with three distinct ratios of hydroxyapatite (HA): tricalcium phosphate (TCP) were produced using a modified extrusion method: HA8 (8%: 92%), HA48 (48%:52%), and HA80 (80%:20%). The blocks were examined using scanning electron microscopy, X-ray diffractometry, and a universal test machine. Four circular defects 8 mm in diameter were made in 12 rabbits. One defect in each animal served as a control, and the other three defects received the BCP blocks. The rabbits were sacrificed at either two weeks (n=6) or eight weeks (n=6) postoperatively. Results: The pore size, porosity, and compressive strength of the three types of bone block were 140-170 mu m, > 70%, and 4-9 MPa, respectively. Histologic and histomorphometric observations revealed that the augmented space was well maintained, but limited bone formation was observed around the defect base and defect margins. No significant differences were found in the amount of new bone formation, graft material resorption, or bone infiltration among the three types of BCP block at either of the postoperative healing points. Conclusions: Block bone substitutes with three distinct compositions (i.e., HA:TCP ratios) processed by a modified extrusion method exhibited limited osteoconductive potency, but excellent space-maintaining capability. Further investigations are required to improve the processing method.
URI
http://hdl.handle.net/YU.REPOSITORY/32689http://dx.doi.org/10.5051/jpis.2015.45.2.46
ISSN
2093-2278
Appears in Collections:
공과대학 > 신소재공학부 > Articles
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