Two new conjugated ketonic fatty acids from the stem bark of JuglJuglans mandshurica

Title
Two new conjugated ketonic fatty acids from the stem bark of JuglJuglans mandshurica
Author(s)
손종근YAO Da-Lei[YAO Da-Lei]ZHANG Chang-Hao[ZHANG Chang-Hao]LI Ren[LI Ren]LUO Jie[LUO Jie]JIN Mei[JIN Mei]PIAO Jin-Hua[PIAO Jin-Hua]ZHENG Ming-Shan[ZHENG Ming-Shan]CUI Jiong-Mo[CUI Jiong-Mo]LI Gao[LI Gao]
Keywords
12 hydroxy 7 oxo 8,10 octadecadienoic acid; 12 hydroxy 7 oxo 8,10 octadecadienoic acid methyl ester; plant extract; polyunsaturated fatty acid; unclassified drug; Article; bark; carbon nuclear magnetic resonance; controlled study; drug isolation; drug structure; high performance liquid chromatography; Juglans mandshurica; proton nuclear magnetic resonance; walnut
Issue Date
201504
Citation
Chinese Journal of Natural Medicines, v.13, no.4, pp.299 - 302
Abstract
The present study was designed to isolate and characterize novel chemical constituents of the stem bark of Juglans mandshurica Maxim. (Juglandaceae). The chemical constituents were isolated and purified by various chromatographic techniques. The structures of the compounds were elucidated on the basis of spectral data (1D and 2D NMR, HR-ESI-MS, CD, UV, and IR) and by the comparisons of spectroscopic data with the reported values in the literatures. Two long chain polyunsaturated fatty acids (1 and 2) were obtained and identified as (S)-(8E,10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid (1) and (S)-(8. E, 10. E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid methyl ester (2). To the best of our knowledge, this is the first report on the isolation and structural elucidation of the two new conjugated ketonic fatty acids from this genus. ? 2015 China Pharmaceutical University.
URI
http://hdl.handle.net/YU.REPOSITORY/32673http://dx.doi.org/10.1016/S1875-5364(15)30018-2
ISSN
1875-5364
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약학대학 > 약학부 > Articles
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