A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects

Title
A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects
Author(s)
이승호최현규최연호김지향김희훈[김희훈]김상현[김상현]이상명[이상명]나민균[나민균]김정안[김정안]
Issue Date
201404
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.37, no.4, pp.467 - 472
Abstract
A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8'R)-acuminatolide (6), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher's esterification. The effect of compounds 1-7 on tumor necrosis factor (TNF)-alpha, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-alpha, and IL-6 in human mast cells. Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.
URI
http://hdl.handle.net/YU.REPOSITORY/32633http://dx.doi.org/10.1007/s12272-013-0239-7
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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