Aerosol-Processed Thermosensitive Nanocomposites for Controlled Drug Release

Title
Aerosol-Processed Thermosensitive Nanocomposites for Controlled Drug Release
Author(s)
변정훈김장우[김장우]
Keywords
COMPOSITE MICROSPHERES; CROSS-LINKERS; MAGNETIC CORE; NANOPARTICLES; MICROGELS
Issue Date
201404
Publisher
AMER CHEMICAL SOC
Citation
ACS MACRO LETTERS, v.3, no.4, pp.369 - 373
Abstract
In this study, an ambient-spark-produced iron (Fe)-nanoparticle-laden nitrogen gas was mixed with an atomized solution of N-isopropylacrylamide (NIPAM)-polydimethylsiloxane (PDMS). The Fe nanoparticles reacted with NIPAM-PDMS in the atomized droplets to form encapsulated Fe nanoparticles, i.e., Fe@NIPAM-PDMS nanocomposites, whose size distribution was unimodal (showing only a NIPAM-PDMS-like distribution, with the Fe distribution eliminated). By varying processing temperatures, it was possible to obtain Fe@NIPAM-PDMS nanocomposites with different sizes and morphologies. This is further attributed to the quantitative incorporation of Fe nanoparticles into atomized NIPAM-PDMS-doxorubicin (DOX) droplets. The Fe@NIPAM-PDMS-DOX nanocomposites released different amounts of DOX under a magnetothermal effect, which produced different levels of cytotoxic effects on the targeted HeLa cells. The thermosensitivity makes these nanocomposites an ideal candidate for important applications such as controlled drug delivery.
URI
http://hdl.handle.net/YU.REPOSITORY/32560http://dx.doi.org/10.1021/mz500142e
ISSN
2161-1653
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공과대학 > 기계공학부 > Articles
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