Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways

Title
Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways
Author(s)
김화영이유진곽근희캠블크란티
Keywords
OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM; RESISTANCE; DROSOPHILA; P53; OVEREXPRESSION; PROTECTS; MSRB1; ROLES; ACTIN
Issue Date
201404
Publisher
ELSEVIER SCIENCE INC
Citation
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v.547, pp.1 - 5
Abstract
Methionine sulfoxide reductase B3 (MsrB3) is an oxidoreductase in the endoplasmic reticulum that catalyzes the stereospecific reduction of methionine-R-sulfoxide to methionine. Here, we report the critical role and mechanisms of MsrB3 in cell proliferation. The deletion of MsrB3 led to a significant decrease in cell proliferation in mouse embryonic fibroblast (MEF) cells. MsrB3-knockout MEF cells showed increased p53 protein levels, compared to wild-type MEF cells, which subsequently elevated the protein level of cyclin-dependent kinase inhibitor p21. In addition, MsrB3 deficiency enhanced the protein level of p27, another cell cycle regulator, and caused cell cycle arrest at the G (1) stage. The inhibitory effect of MsrB3 deficiency on cell proliferation through the activation of p53-p21 and p27 pathways was also confirmed in primary human dermal fibroblasts. Collectively, the data suggest that MsrB3 is a regulator of cell growth through the p53-p21 and p27 pathways. (C) 2014 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/32557http://dx.doi.org/10.1016/j.abb.2014.02.0080003-9861
ISSN
0003-9861
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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