Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways
- Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways
- 김화영; 이유진; 곽근희; 캠블크란티
- OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM; RESISTANCE; DROSOPHILA; P53; OVEREXPRESSION; PROTECTS; MSRB1; ROLES; ACTIN
- Issue Date
- ELSEVIER SCIENCE INC
- ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v.547, pp.1 - 5
- Methionine sulfoxide reductase B3 (MsrB3) is an oxidoreductase in the endoplasmic reticulum that catalyzes the stereospecific reduction of methionine-R-sulfoxide to methionine. Here, we report the critical role and mechanisms of MsrB3 in cell proliferation. The deletion of MsrB3 led to a significant decrease in cell proliferation in mouse embryonic fibroblast (MEF) cells. MsrB3-knockout MEF cells showed increased p53 protein levels, compared to wild-type MEF cells, which subsequently elevated the protein level of cyclin-dependent kinase inhibitor p21. In addition, MsrB3 deficiency enhanced the protein level of p27, another cell cycle regulator, and caused cell cycle arrest at the G (1) stage. The inhibitory effect of MsrB3 deficiency on cell proliferation through the activation of p53-p21 and p27 pathways was also confirmed in primary human dermal fibroblasts. Collectively, the data suggest that MsrB3 is a regulator of cell growth through the p53-p21 and p27 pathways. (C) 2014 Elsevier Inc. All rights reserved.
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