Transition-Metal-Free Benzannulation for Diverse and Polyfunctionalized Biaryl Formation

Title
Transition-Metal-Free Benzannulation for Diverse and Polyfunctionalized Biaryl Formation
Author(s)
이용록테즈나라얀포우델
Keywords
CATALYZED DIRECT ARYLATION; FISCHER CARBENE COMPLEXES; DIELS-ALDER REACTION; MICHAEL ADDITION; MULTICOMPONENT REACTIONS; DOMINO REACTIONS; TERT-BUTOXIDE; SIMPLE ARENES; DERIVATIVES; CONSTRUCTION
Issue Date
201505
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v.17, no.9, pp.2050 - 2053
Abstract
A novel and efficient synthesis of highly functionalized and diverse biaryls via mild base-promoted transition-metal-free benzannulation was achieved in good yield from readily available beta-ketoesters, beta-ketoamides, or 1,3-diketones With cinnamaldehydes or aryl aldehydes. This transformation comprises a sequence of the formation of three new bonds through multicomponent reactions as a one pot procedure. This novel biaryl formation proceeds through domino Michael addition/intramolecular and intermolecular aldol/[1,5]-hydrogen shift/tautomerization. This protocol provides a great advantage in introducing various functional groups, on the aromatic ring of biaryls.
URI
http://hdl.handle.net/YU.REPOSITORY/32549http://dx.doi.org/10.1021/acs.orglett.5b00996
ISSN
1523-7060
Appears in Collections:
공과대학 > 화학공학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE