Formation of Poly[d(A-T)(2)] Specific Z-DNA by a Cationic Porphyrin
- Formation of Poly[d(A-T)(2)] Specific Z-DNA by a Cationic Porphyrin
- 장윤정; 김석규; 이창윤
- CIRCULAR-DICHROISM; BINDING DOMAIN; COMPLEX; SALT; STACKING; TRIPLEX; NMR
- Issue Date
- NATURE PUBLISHING GROUP
- SCIENTIFIC REPORTS, v.5
- Typical CD spectrum of the right-handed poly[d(A-T)(2)] was reversed when trans-bis(Nmethylpyrimidium- 4-yl) diphenyl porphyrin (trans-BMPyP) was bound, suggesting that the helicity of the polynucleotide was reversed to the left-handed form. The formation of the left-handed Z-form poly[d(A-T)(2)] was confirmed by P-31 NMR, in which a single P-31 peak of B-form poly[d(A-T)(2)] was split into two peaks, which is similar to the conventional B-Z transition of poly[d(G-C)(2)] induced by the high ionic strength. The observed B-Z transition is unique for poly[d(A-T)(2)]. The other polynucleotides, including poly[d(G-C)(2)], poly(dG)center dot poly(dC) and poly(dA)center dot poly(dT) remained as the right-handed form in the presence of the same porphyrin. This observation suggests that the porphyrin array that was formed along the poly[d(A-T)(2)] provides a template to which left-handed poly[d(A-T)(2)] is associated with an electrostatic interaction.
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