Formation of Poly[d(A-T)(2)] Specific Z-DNA by a Cationic Porphyrin

Title
Formation of Poly[d(A-T)(2)] Specific Z-DNA by a Cationic Porphyrin
Author(s)
장윤정김석규이창윤
Keywords
CIRCULAR-DICHROISM; BINDING DOMAIN; COMPLEX; SALT; STACKING; TRIPLEX; NMR
Issue Date
201505
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.5
Abstract
Typical CD spectrum of the right-handed poly[d(A-T)(2)] was reversed when trans-bis(Nmethylpyrimidium- 4-yl) diphenyl porphyrin (trans-BMPyP) was bound, suggesting that the helicity of the polynucleotide was reversed to the left-handed form. The formation of the left-handed Z-form poly[d(A-T)(2)] was confirmed by P-31 NMR, in which a single P-31 peak of B-form poly[d(A-T)(2)] was split into two peaks, which is similar to the conventional B-Z transition of poly[d(G-C)(2)] induced by the high ionic strength. The observed B-Z transition is unique for poly[d(A-T)(2)]. The other polynucleotides, including poly[d(G-C)(2)], poly(dG)center dot poly(dC) and poly(dA)center dot poly(dT) remained as the right-handed form in the presence of the same porphyrin. This observation suggests that the porphyrin array that was formed along the poly[d(A-T)(2)] provides a template to which left-handed poly[d(A-T)(2)] is associated with an electrostatic interaction.
URI
http://hdl.handle.net/YU.REPOSITORY/32538http://dx.doi.org/10.1038/srep09943
ISSN
2045-2322
Appears in Collections:
문과대학 > 중국언어문화학과 > Articles
이과대학 > 화학생화학부 > Articles
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