Antimycotic potential of a diterpenoid taxoquinone against Candida species isolated from Metasequoia glyptostroboides

Title
Antimycotic potential of a diterpenoid taxoquinone against Candida species isolated from Metasequoia glyptostroboides
Author(s)
비벡바지파이강선철[강선철]
Keywords
MIKI EX HU; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL; ALBICANS; AGENTS
Issue Date
201404
Publisher
BANGLADESH PHARMACOLOGICAL SOC
Citation
BANGLADESH JOURNAL OF PHARMACOLOGY, v.9, no.2, pp.154 - 160
Abstract
The objective of this study was to confirm the antimycotic potential of a diterpenoid compound taxoquinone, isolated from Metasequoia glyptostroboides against pathogenic isolates of Candida species. The taxoquinone (100 mu g/disc) displayed potential anticandidal effect against Candia albicans KBN06P00076, KBN06P00074, C. glabrata KBN06P00066, KBN06P00068, C. tropicalis KBN06P00682, KBN06P00058, C. parapsilosis KBN06P00060, KBN06P00055, and C. guilliermondii KBN06P00492 and KBN06P00867 as a diameter of zones of inhibition, found in the range of 10 +/- 0.6 to 13 +/- 1.1 mm. The minimum inhibitory and minimum fungicidal concentrations of taxoquinone against the tested clinical isolates were found in the range of 125 to 500 and 125 to 1,000 mu g/mL, respectively. On the viable counts of the tested fungal isolates, the taxoquinone evoked a remarkable anticandidal effect. Elaborative study of SEM revealed potential detrimental effect of taxoquinone on the morphology of C. parapsilosis KBN06P00060 at MIC concentration. These findings confirmed therapeutic potential of taxoquinone.
URI
http://hdl.handle.net/YU.REPOSITORY/32529http://dx.doi.org/10.3329/bjp.v9i2.17555
ISSN
1991-007X
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중앙도서관 > rims journal
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