Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-.B Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.

Title
Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-.B Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
Author(s)
최혁재김희영[김희영]김광진[김광진]윤정태[윤정태]김성환[김성환]원동환[원동환]남상집[남상집]손영진[손영진]강헌중[강헌중]
Keywords
ACETYLENIC ACIDS; GENE-EXPRESSION; MARINE SPONGE; NFATC1; POLYACETYLENES; CELLS
Issue Date
201404
Publisher
MDPI AG
Citation
MARINE DRUGS, v.12, no.4, pp.2054 - 2065
Abstract
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-B ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 M while placotylene B (2) did not show any significant activity up to 100 M, respectively.
URI
http://hdl.handle.net/YU.REPOSITORY/32524http://dx.doi.org/10.3390/md12042054
ISSN
1660-3397
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약학대학 > 약학부 > Articles
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