In Vivo Wound-Healing Effects of Novel Benzalkonium Chloride-Loaded Hydrocolloid Wound Dressing

Title
In Vivo Wound-Healing Effects of Novel Benzalkonium Chloride-Loaded Hydrocolloid Wound Dressing
Author(s)
용철순진성기[진성기]Abid Mehmood Yousaf[Abid Mehmood Yousaf]장선우[장선우]손마원[손마원]김동욱[김동욱]Dong Xun Li[Dong Xun Li]김종오최한곤[최한곤]김경수[김경수]
Keywords
SODIUM ALGINATE; POLYVINYL-ALCOHOL; CHITOSAN; DELIVERY; SKIN; COMPOSITE; HYDROGELS; RELEASE; SYSTEM; MATRIX
Issue Date
201505
Publisher
WILEY-BLACKWELL
Citation
DRUG DEVELOPMENT RESEARCH, v.76, no.3, pp.157 - 165
Abstract
The purpose of this study was to evaluate the wound-healing effects of a novel benzalkonium chloride (BC)-loaded hydrocolloid wound dressing (HCD). A BC-loaded HCD was prepared with various constituents using a hot melting method, and its mechanical properties and antimicrobial activities were assessed. The in vivo wound healings of the BC-loaded HCD in various would models were evaluated in rats compared with a commercial wound dressing, Duoderm. This BC-loaded HCD gave better skin adhesion, swelling, mechanical strength, and flexibility compared with the commercial wound dressing. It showed excellent antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In addition, as compared with the commercial wound dressing, it showed more improved wound healings and tissue restoration effect on the excision, infection, and abrasion wounds in rats. Thus, this novel BC-loaded HCD would be an excellent alternative to the commercial wound dressing for treatment of various wounds. Drug Dev Res 73 : 157-165, 2015. (c) 2015 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/YU.REPOSITORY/32507http://dx.doi.org/10.1002/ddr.21253
ISSN
0272-4391
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약학대학 > 약학부 > Articles
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