Enantiomer separation of acidic chiral compounds on a quinine-silica/zirconia hybrid monolith by capillary electrochromatography

Title
Enantiomer separation of acidic chiral compounds on a quinine-silica/zirconia hybrid monolith by capillary electrochromatography
Author(s)
박정학트란녹레
Keywords
PERFORMANCE LIQUID-CHROMATOGRAPHY; DERIVATIZED AMINO-ACIDS; STATIONARY PHASES; ANION-EXCHANGERS; SURFACE FUNCTIONALIZATION; ELECTROOSMOTIC FLOW; SILICA MONOLITHS; COLUMN; ENANTIOSEPARATION; ZIRCONIA
Issue Date
201505
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CHROMATOGRAPHY A, v.1396, pp.140 - 147
Abstract
A weak anion-exchanger chiral selector, quinine-incorporated silica/zirconia hybrid monolithic (QUI-S/ZHM) capillary column was prepared by sol-gel technology. The performance of the QUI-S/ZHM column was investigated for enantioresolution of a set of acidic chiral drugs and dinitrobenzoyl (DNB)-amino acids by capillary electrochromatography in aqueous organic mobile phases composed of acetonitrile (ACN) and triethylammonium acetate (TEAA) buffer. Effects of several parameters including the ACN content, concentration and pH of the mobile phase on the chiral separation were examined. Baseline resolutions of all the compounds were obtained in the mobile phase consisting of 70:30 ACN/TEAA (10 mM, pH 6) under applied voltage of -10 kV at 25 degrees C within 20 min. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/32501http://dx.doi.org/10.1016/j.chroma.2015.03.085
ISSN
0021-9673
Appears in Collections:
이과대학 > 화학생화학부 > Articles
문과대학 > 중국언어문화학과 > Articles
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