Utility of the Rio Score and Modified Rio Score in Korean Patients with Multiple Sclerosis

Title
Utility of the Rio Score and Modified Rio Score in Korean Patients with Multiple Sclerosis
Author(s)
박민수현재원[현재원]김수현[김수현]정인혜[정인혜]안석원[안석원]허소영[허소영]주인수[주인수]민주홍[민주홍]김병준[김병준]김호진[김호진]
Keywords
INTERFERON-BETA; DISEASE; DISABILITY; THERAPIES; CRITERIA; LESIONS; TRIAL
Issue Date
201505
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.10, no.5
Abstract
Objectives Early identification of suboptimal responders to multiple sclerosis (MS) treatment is critical for optimizing therapeutic decisions. The Rio score (RS) and modified Rio score (MRS) were developed to discriminate the responses to interferon-beta (IFNB) treatment in MS patients. This study was performed to evaluate the utility of RS and MRS in daily clinical practice in Korea. Methods This was a real-world setting, multicenter, retrospective study of MS patients treated with IFNB from 10 hospitals in Korea. We investigated whether the RS and MRS at the early stage of IFNB therapy could predict treatment responses over 3 years. Suboptimal treatment responses at 3 years were defined as the presence of clinical relapse and/or EDSS progression and/or patients who had been treated with INFB for at least for 1 year and therapy was switched due to perceived treatment failure during the 2 years of follow-up. Results Seventy patients (50 females and 20 males) were enrolled; 92% (12/13) of patients with high RS and 86% (12/14) of patients with high MRS (score 2 or 3) were suboptimal responders, whereas 93% (53/57) of patients with low RS and 93% (52/56) patients with low MRS (score 0 or 1) showed optimal responses. New active lesions on MRI with clinical relapse in high RS and MRS were the most common combination in suboptimal responders. Conclusions We confirmed that RS and MRS at 6-15 months of IFNB therapy were useful for predicting poor responders over 3 years.
URI
http://hdl.handle.net/YU.REPOSITORY/32491http://dx.doi.org/10.1371/journal.pone.0129243
ISSN
1932-6203
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의과대학 > 신경과학교실 > Articles
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