Enantiomer separations of basic chiral compounds by capillary electrochromatography on a phosphated beta-cyclodextrin-modified zirconia monolith
- Enantiomer separations of basic chiral compounds by capillary electrochromatography on a phosphated beta-cyclodextrin-modified zirconia monolith
- 박정학; 박진명
- PERFORMANCE LIQUID-CHROMATOGRAPHY; 2,4-DINITROPHENYL AMINO-ACIDS; CARBON-CLAD ZIRCONIA; STATIONARY PHASES; COATED ZIRCONIA; IMMOBILIZED ZIRCONIA; ELECTROOSMOTIC FLOW; RECENT INNOVATIONS; CONTINUOUS BEDS; ELECTROPHORESIS
- Issue Date
- ELSEVIER SCIENCE BV
- JOURNAL OF CHROMATOGRAPHY A, v.1339, pp.229 - 233
- Phosphated beta-cyclodextrin (PCD)-coated zirconia monolith was used as the chiral stationary phase in capillary electrochromatography (CEC) for separation of four basic chiral compounds including metoprolol (MET), sertraline (SER), citalopram (CIT) and atenolol (ATE). Migration, chiral selectivity and resolution data were measured in reversed-phase mobile phases of varying pH, buffer and organic modifier compositions. Optimum mobile phase conditions for CEC separation of the compounds studied were found to be a 15-mM aqueous buffer of pH 5.0 with 5 mM PCD. Baseline separations of enantiomers of CIT, MET and SER, and partial separation for ATE were achieved with the optimal mobile phase. (C) 2014 Elsevier B.V. All rights reserved.
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