Enantiomer separations of basic chiral compounds by capillary electrochromatography on a phosphated beta-cyclodextrin-modified zirconia monolith

Title
Enantiomer separations of basic chiral compounds by capillary electrochromatography on a phosphated beta-cyclodextrin-modified zirconia monolith
Author(s)
박정학박진명
Keywords
PERFORMANCE LIQUID-CHROMATOGRAPHY; 2,4-DINITROPHENYL AMINO-ACIDS; CARBON-CLAD ZIRCONIA; STATIONARY PHASES; COATED ZIRCONIA; IMMOBILIZED ZIRCONIA; ELECTROOSMOTIC FLOW; RECENT INNOVATIONS; CONTINUOUS BEDS; ELECTROPHORESIS
Issue Date
201404
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CHROMATOGRAPHY A, v.1339, pp.229 - 233
Abstract
Phosphated beta-cyclodextrin (PCD)-coated zirconia monolith was used as the chiral stationary phase in capillary electrochromatography (CEC) for separation of four basic chiral compounds including metoprolol (MET), sertraline (SER), citalopram (CIT) and atenolol (ATE). Migration, chiral selectivity and resolution data were measured in reversed-phase mobile phases of varying pH, buffer and organic modifier compositions. Optimum mobile phase conditions for CEC separation of the compounds studied were found to be a 15-mM aqueous buffer of pH 5.0 with 5 mM PCD. Baseline separations of enantiomers of CIT, MET and SER, and partial separation for ATE were achieved with the optimal mobile phase. (C) 2014 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/32489http://dx.doi.org/10.1016/j.chroma.2014.03.008
ISSN
0021-9673
Appears in Collections:
이과대학 > 화학생화학부 > Articles
문과대학 > 중국언어문화학과 > Articles
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