Effect of Emollients Containing Vegetable-Derived Lactobacillus in the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial

Title
Effect of Emollients Containing Vegetable-Derived Lactobacillus in the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial
Author(s)
박용하Seung Bae Park[Seung Bae Park]Myung Im[ Myung Im]Young Lee[Young Lee]Jeung Hoon Lee[ Jeung Hoon Lee]임정희Young Joon Seo[Young Joon Seo]
Keywords
INTESTINAL PERMEABILITY; IN-VITRO; PROBIOTICS; PLANTARUM; CHILDREN; ECZEMA; BURNS
Issue Date
201404
Publisher
KOREAN DERMATOLOGICAL ASSOC
Citation
ANNALS OF DERMATOLOGY, v.26, no.2, pp.150 - 155
Abstract
Background: Atopic dermatitis (AD) patients suffer from xerosis. Proper skin care, including the use of emollients, may help improve xerosis and minimize disease exacerbation. Lactobacillus sakei probio 65, isolated from the Korean vegetable-based product kimchi, can decrease interleukin 4 and immunoglobulin E levels and inhibit Staphylococcus aureus. Moreover, it has reportedly shown positive dermatological effects in both animal and clinical studies. Objective: To compare the effects of an emollient that contains Lactobacillus (treated) with a normal emollient (control) on AD. Methods: This double-blind, randomized, split-body clinical trial involved 28 patients with AD. The patients applied the Lactobacillus-containing emollient on one side of their body and the control emollient on the other side twice daily for 4 weeks. Trans-epidermal water loss (TEWL) and skin capacitance were evaluated and investigator global assessment and the visual analogue scale (VAS) were administered on weeks 0, 1, 2, and 4. Results: The treated sides had significantly lower TEWL and VAS values and significantly higher skin capacitance values over time than the control sides. Conclusion: Topical application of Lactobacillus-containing emollients may improve the skin permeability of patients with AD.
URI
http://hdl.handle.net/YU.REPOSITORY/32485http://dx.doi.org/10.5021/ad.2014.26.2.150
ISSN
1013-9087
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생명공학부 > 생명공학부 > Articles
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