Multifunctional Adhesive Silk Fibroin with Blending of RGD-Bioconjugated Mussel Adhesive Protein

Title
Multifunctional Adhesive Silk Fibroin with Blending of RGD-Bioconjugated Mussel Adhesive Protein
Author(s)
서정현양윤정[양윤정]권윤경[권윤경]최봉혁[최봉혁]정두엽[정두엽]이기훈[이기훈]차형준[차형준]
Keywords
FACILE SURFACE FUNCTIONALIZATION; CELL-ADHESION; ESCHERICHIA-COLI; MECHANICAL-PROPERTIES; PHYSICAL-PROPERTIES; MYTILUS-EDULIS; IN-VIVO; DIFFERENTIATION; PROLIFERATION; BIOMATERIALS
Issue Date
201404
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.15, no.4, pp.1390 - 1398
Abstract
Silk has recently been exploited in various fields due to its superior mechanical properties. However, this material's lack of biological functions and relatively poor biodegradation have hindered its wide use in applications related to cells and tissues. Here, we improved the overall characteristics of silkworm silk fibroin (SF) by introduction of RGD peptide-fused recombinant mussel adhesive protein (MAP-RGD). Simple blending of MAP-RGD provided not only bulk-scale adhesive ability but also microscale adhesiveness to cells and various biomolecules. MAP-RGD-blended SF fibers supported enhanced adhesion, proliferation, and spreading of mammalian cells as well as the efficient attachment of biomolecules, including carbohydrate and protein. In addition, the hydrophilicity, swelling, and biodegradability of the MAP-RGD-blended SF material were improved without notable hampering of the original mechanical properties of SF. Therefore, the adhesive silk fibrous scaffold could be successfully used in diverse biomedical engineering applications.
URI
http://hdl.handle.net/YU.REPOSITORY/32475http://dx.doi.org/10.1021/bm500001n
ISSN
1525-7797
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공과대학 > 화학공학부 > Articles
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