Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts

Title
Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts
Author(s)
김재룡양효현황보경Ming Shan Zheng[Ming Shan Zheng]조정희손종근김화영백석환최형철박소영
Keywords
CELLS
Issue Date
201505
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.38, no.5, pp.876 - 884
Abstract
Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases. In this study, we investigated whether (-)-loliolide purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). (-)-Loliolide diminished senescence-associated beta-galactosidase activity (SA-beta-gal), the level of p21 protein, and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. (-)-Loliolide also attenuated SA-beta-gal activity in HDFs under replicative senescence. These findings imply that (-)-loliolide rescues cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or age-associated diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/32458http://dx.doi.org/10.1007/s12272-014-0435-0
ISSN
0253-6269
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
약학대학 > 약학부 > Articles
의과대학 > 약리학교실 > Articles
의과대학 > 생리학교실 > Articles
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