Cytokine Expression of Microscopic Colitis Including Interleukin-17

Title
Cytokine Expression of Microscopic Colitis Including Interleukin-17
Author(s)
장병익Young Sook Park[Young Sook Park]Eunkyoung Park[Eunkyoung Park]Dae Rim Park[Dae Rim Park]Dong Soo Han[Dong Soo Han]Won Ho Kim[Won Ho Kim]Sung Ae Jung[Sung Ae Jung]Young Ho Kim[Young Ho Kim]조윤주[조윤주]이기호[이기호]
Keywords
INFLAMMATORY-BOWEL-DISEASE; COLLAGENOUS COLITIS; PROFILE; CANCER; CELLS
Issue Date
201505
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v.9, no.3, pp.381 - 387
Abstract
Background/Aims: Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the pathogenic mechanism of microscopic colitis. Methods: This study consisted of six patients with lymphocytic colitis, six patients with collagenous colitis, and six patients with functional diarrhea but normal pathology. We performed an immunohistochemical analysis of the colonic mucosal biopsies to assess the expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-kappa B, interferon-gamma, inducible nitric oxide synthase, and tumor necrosis factor-alpha. We compared the quantity score of immunohistochemical staining among the groups. Results: The microscopic colitis group showed significantly higher expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-kappa B, and interferon-gamma compared with the control group. Cytokine expression was similar between collagenous colitis and lymphocytic colitis. However, the expression of cyclo-oxygenase-2 was higher in collagenous colitis. Conclusions: Proinflammatory cytokines, including interleukin-17 and interferon-gamma, are highly expressed in microscopic colitis. The expression of cyclo-oxygenase-2 was higher in collagenous colitis than in lymphocytic colitis. This study is the first on interleukin-17 expression in microscopic colitis patients.
URI
http://hdl.handle.net/YU.REPOSITORY/32437http://dx.doi.org/10.5009/gnl13439
ISSN
1976-2283
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의과대학 > 내과학교실 > Articles
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