High-dose Vitamin C therapy in Methemoglobinemia
- High-dose Vitamin C therapy in Methemoglobinemia
- 박신률; 이경우[이경우]; 강태신[강태신]
- Methemoglobinemia; Vitamin C; Dapsone; Methylene blue
- Issue Date
- 대한응급의학회지, v.25, no.2, pp.202 - 205
- Methylene blue is the first choice antidote for managementof methemoglobinemia, however, some patients are refractoryto methylene blue and in most cases, methylene bluecannot be available instantly in Korean emergency departmentsbecause of import suspension. A 69-year-old womanvisited our emergency department for tachypnea andcyanosis after ingesting 30 tablets of dapsone. Becausemethylene blue was not available, we intravenously administrated10 g of vitamin C for symptomatic methemoglobinemia.
Repeated i.v. administrations of 10 g of vitamin C inpatient without preexisting renal insufficiency successfullytreated dapsone-induced methemoglobinemia withoutcausing renal complications. Thus, we recommend that ifmethylene blue is unavailable or methemoglobinemia isrefractory to methylene blue, repeated administrations of 10g of vitamin C may be considered for the treatment ofmethemoglobinemia in patients without renal insufficiency.
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