Efficient one-pot protocol for diverse pyrazolylphosphonates by multi-component reactions: their antioxidant and antibacterial activities

Title
Efficient one-pot protocol for diverse pyrazolylphosphonates by multi-component reactions: their antioxidant and antibacterial activities
Author(s)
이용록강소랑
Keywords
STATE ANALOG INHIBITORS; BIOLOGICAL-ACTIVITY; ACID-DERIVATIVES; RENIN INHIBITORS; PHOSPHITES; ESTERS; PHOSPHONATES; CATALYST; PYRAZOLE; ALKENES
Issue Date
201505
Publisher
SPRINGER
Citation
MOLECULAR DIVERSITY, v.19, no.2, pp.293 - 304
Abstract
Efficient one-pot three-component reactions of pyrazolones with arylaldehydes and triethyl phosphite were carried out in the presence of ethylenediammonium diacetate as catalyst to synthesize biologically interesting pyrazolylphosphonate derivatives. This methodology offers several significant advantages such as environmentally benign character, the use of a mild catalyst, high yields, and ease of handling. The synthesized compounds were screened for their antioxidant and antibacterial activities. The result showed that compound 4d exhibited a strong free radical scavenger toward DPPH free radicals compared with standard BHT . In addition, compounds 4e and 4p showed potent antibacterial activities against Gram-negative bacteria of E. coli and compound 4o exhibited a potent activity against Gram-positive bacteria of S. aureus compared with standard Ampicillin. [GRAPHICS] .
URI
http://hdl.handle.net/YU.REPOSITORY/32281http://dx.doi.org/10.1007/s11030-015-9568-4
ISSN
1381-1991
Appears in Collections:
공과대학 > 화학공학부 > Articles
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