Aurantio-Obtusin Stimulates Chemotactic Migration and Differentiation of MC3T3-E1 Osteoblast Cells

Title
Aurantio-Obtusin Stimulates Chemotactic Migration and Differentiation of MC3T3-E1 Osteoblast Cells
Author(s)
체타라비쉬누프라사드한성수토모코투시야시로가네가사키김준호
Keywords
CASSIA-OBTUSIFOLIA; HUMAN KERATINOCYTES; SEMEN CASSIAE; WATER EXTRACT; OSTEOPOROSIS; EPIDEMIOLOGY; PREVENTION; APOPTOSIS; DIAGNOSIS; MODEL
Issue Date
201405
Publisher
GEORG THIEME VERLAG KG
Citation
PLANTA MEDICA, v.80, no.7, pp.544 - 549
Abstract
Osteoporosis is one of the major metabolic bone diseases and is among the most challenging noncommunicable diseases to treat. Although there is an increasing interest in identifying bioactive molecules for the prevention and management of osteoporosis, such studies principally focus only on differentiation and mineralization of osteoblasts or inhibition of osteoclast activity. Stimulation of osteoblast migration must be a promising osteoanabolic strategy for improved metabolic bone disease therapy. In this study, we show that an anthraquinone derivative, aurantio-obtusin, stimulated chemotactic migration of MC3T3-E1 osteoblast cells in a concentration-dependent manner. The use of a real-time chemotaxis analyzing system, TAXIScan, facilitated the evaluation of both velocity and directionality of osteoblast migration in response to the compound. Besides migration, the compound stimulated osteoblast differentiation and mineralization. Taken together, the data presented in this paper demonstrate that aurantio-obtusin is a promising osteoanabolic compound of natural origin with potential therapeutic applications in the prevention of osteoporosis and other metabolic bone diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/32271http://dx.doi.org/10.1055/s-0034-1368445
ISSN
0032-0943
Appears in Collections:
중앙도서관 > rims journal
공과대학 > 화학공학부 > Articles
의과대학 > 생화학.분자생물학교실 > Articles
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