Engineering and Optimization of Three-Dimensional Poly(vinyl alcohol)/Gelatin Matrix to Mimic Skin Tissue

Title
Engineering and Optimization of Three-Dimensional Poly(vinyl alcohol)/Gelatin Matrix to Mimic Skin Tissue
Author(s)
한성수최순모
Keywords
GELATIN SCAFFOLDS; CROSS-LINKING; GLUTARALDEHYDE; BIODEGRADATION; BLENDS; FILMS; CULTURE
Issue Date
201505
Publisher
AMER SCIENTIFIC PUBLISHERS
Citation
JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE, v.12, no.5, pp.858 - 866
Abstract
Scaffold fabricated for dermal reconstruction is prepared using various techniques and different parameters. In this study we have fabricated novel PVA/gelatin (PG) matrices through a foaming technique. Different analysis was performed to check for physico-chemical properties of the matrices, such as water absorption, degradation, pore-size and mechanical properties. Furthermore, an in-vitro cell culture study performed showed that the porous matrices were suitable for cellular adhesion and proliferation and depending upon the polymer ratio, cells showed difference in metabolic activity examined using MU, scanning electron microscopy and DAPI staining. In addition, along with cell biocompatibility the biodegradation study showed the porous matrices physically degraded in phosphate buffer at pH 7.4. It was further explored for drug release and it was seen that the rate degradation of the matrix was proportional to drug release from the matrix. The degradation was controlled by changing the polymer ratio during the matrix fabrication thereby altering the amount of drug release from the matrix. This article is focused on exploratory details indicates that the properties and drug release characteristics of the matrix have potential applications in skin tissue engineering.
URI
http://hdl.handle.net/YU.REPOSITORY/32267http://dx.doi.org/10.1166/jctn.2015.3817
ISSN
1546-1955
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공과대학 > 화학공학부 > Articles
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