Long-Term Results of Adipose-Derived Stem Cell Therapy for the Treatment of Crohn's Fistula

Title
Long-Term Results of Adipose-Derived Stem Cell Therapy for the Treatment of Crohn's Fistula
Author(s)
정상훈유창식[유창식]박규주[박규주]조용범[조용범]윤상남[윤상남]송기호[송기호]김도선[김도선]김미형[김미형]정희영[정희영]
Keywords
MESENCHYMAL STROMAL CELLS; COMPLEX PERIANAL FISTULAS; SURGICAL-TREATMENT; SETON TREATMENT; PHASE-I; DISEASE; MANAGEMENT; INFLIXIMAB; CLASSIFICATION; AZATHIOPRINE
Issue Date
201505
Publisher
ALPHAMED PRESS
Citation
STEM CELLS TRANSLATIONAL MEDICINE, v.4, no.5, pp.532 - 537
Abstract
A previous phase II clinical trial of adipose-derived stem cell (ASC) therapy for fistulae associated with Crohn's disease, a devastating condition with a high recurrence rate, demonstrated safety and therapeutic potential with a 1-year sustained response. In the present study, 41 of the 43 phase II trial patients were followed for an additional year, regardless of response in the initial year. At 24 months, complete healing was observed in 21 of 26 patients (80.8%) in modified per protocol analysis and 27 of 36 patients (75.0%) in modified intention-to-treat analysis. No adverse events related to ASC administration were observed. Furthermore, complete closure after initial treatment was well-sustained. These results strongly suggest that autologous ASCs may be a novel treatment option for Crohn's fistulae.
URI
http://hdl.handle.net/YU.REPOSITORY/32245http://dx.doi.org/10.5966/sctm.2014-0199
ISSN
2157-6564
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의과대학 > 성형외과학교실 > Articles
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