Efficacy of Helicobacter pylori eradication for the 1(st) line treatment of immune thrombocytopenia patients with moderate thrombocytopenia

Title
Efficacy of Helicobacter pylori eradication for the 1(st) line treatment of immune thrombocytopenia patients with moderate thrombocytopenia
Author(s)
현명수김혁[김혁]이원식[이원식]이규형[이규형]배성화[배성화]김민경주영돈[주영돈]장대영[장대영]조재철[조재철]이상민[이상민]
Keywords
PURPURA; MANAGEMENT
Issue Date
201505
Publisher
SPRINGER
Citation
ANNALS OF HEMATOLOGY, v.94, no.5, pp.739 - 746
Abstract
The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication as the first line treatment for persistent or chronic ITP patients with moderate thrombocytopenia. Patients with persistent or chronic ITP showing moderate thrombocytopenia (30 x 10(9)/L a parts per thousand currency signaEuro parts per thousand platelet count a parts per thousand currency signaEuro parts per thousand 70 x 10(9)/L) and positive C-13-urea breath test (UBT) were selected. Medication consisted of lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg orally twice daily for a week. Complete response (CR) rate at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 50.0, 50.0, 26.9, and 65.4 %, respectively. Overall response rate (ORR) at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 57.7, 65.4, 30.8, and 69.2 %, respectively. Median maximal platelet count during the first 3 months was 110 x 10(9)/L (range, 40-274). Median time to CR was 8 weeks (95 % CI = 5.429-10.571). Median time to ORR was 4 weeks (95 % CI = 1.228-6.772). Only per-protocol population was a response predictor for ORR at 3 months (70.0 %, p = 0.054) and maximal ORR (80.0 %, p = 0.051), but not for CR at 3 months (60.0 %, p = 0.160). Therefore, eradication of H. pylori is an effective and durable first line treatment for persistent or chronic ITP with moderate thrombocytopenia with high ORR and rapid onset in this study.
URI
http://hdl.handle.net/YU.REPOSITORY/32243http://dx.doi.org/10.1007/s00277-014-2268-9
ISSN
0939-5555
Appears in Collections:
의과대학 > 내과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE