Mussel-Mimetic Protein-Based Adhesive Hydrogel

Title
Mussel-Mimetic Protein-Based Adhesive Hydrogel
Author(s)
서정현김범진[김범진]오동엽[오동엽]김상식[김상식]황동수[황동수]Admir Masic[Admir Masic]한동근[한동근]차형준[차형준]
Keywords
CROSS-LINKING; TISSUE ADHESIVE; CATECHOL; DOPA; SEALANT; BIOADHESIVE; GELATION; COATINGS; POLYMER; IRON
Issue Date
201405
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.15, no.5, pp.1579 - 1585
Abstract
Hydrogel systems based on cross-linked polymeric materials which could provide both adhesion and cohesion in wet environment have been considered as a promising formulation of tissue adhesives. Inspired by marine mussel adhesion, many researchers have tried to exploit the 3,4-dihydroxyphenylalanine (DOPA) molecule as a cross-linking mediator of synthetic polymer-based hydrogels which is known to be able to achieve cohesive hardening as well as adhesive bonding with diverse surfaces. Beside DOPA residue, composition of other amino acid residues and structure of mussel adhesive proteins (MAPs) have also been considered important elements for mussel adhesion. Herein, we represent a novel protein-based hydrogel system using DOPA-containing recombinant MAP. Gelation can be achieved using both oxdiation-induced DOPA quinone-mediated covalent and Fe3+-mediated coordinative noncovalent cross-linking. Fe3+-mediated hydrogels show deformable and self-healing viscoelastic behavior in rheological analysis, which is also well-reflected in bulk adhesion strength measurement. Quinone-mediated hydrogel has higher cohesive strength and can provide sufficient gelation time for easier handling. Collectively, our newly developed MAP hydrogel can potentially be used as tissue adhesive and sealant for future applications.
URI
http://hdl.handle.net/YU.REPOSITORY/32174http://dx.doi.org/10.1021/bm4017308
ISSN
1525-7797
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공과대학 > 화학공학부 > Articles
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