Relationship between serum vitamin D concentrations and clinical outcome of community-acquired pneumonia
- Relationship between serum vitamin D concentrations and clinical outcome of community-acquired pneumonia
- 최은영; 김현정[김현정]; 장종걸; 홍경수; 박진경[박진경]
- D DEFICIENCY; D SUPPLEMENTATION; SEVERITY; INFECTIONS; PREVENTION; IMMUNITY; IMPROVES; INNATE; ASTHMA; COHORT
- Issue Date
- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.19, no.6, pp.729 - 734
- SETTING: Hospitalised patients with community-acquired pneumonia (CAP) in a tertiary referral hospital in South Korea. OBJECTIVE: To determine the burden of vitamin D deficiency in patients hospitalised with CAP and to investigate whether vitamin D deficiency affected clinical outcomes. DESIGN: Serum 25-hydroxyvitamin D (25[OH]D) levels were measured at admission; vitamin D deficiency was defined as 25(OH)D <20 ng/ml. Data were retrospectively analysed for incidence of vitamin D deficiency. The primary outcome was the relationship between serum vitamin D concentration and 28-day all-cause mortality in CAP. RESULTS: The mean age was 68.1 years (standard deviation [SD] +/- 14.6), and the mean pneumonia severity index was 98.0 (+/- SD 28.6). Of the 797 patients (males 66.0%), 641 (80.4%) had vitamin D deficiency. Overall mean serum 25(OH)D level was 14.0 +/- 7.4 ng/ml. The 28-day all-cause mortality rate in vitamin Ddeficient patients was significantly higher than in non-deficient patients (8.3% vs. 2.6%, P = 0.01), and serum vitamin D level was negatively associated with risk of 28-day mortality in CAP after adjustment for pneumonia severity index and serum lactate levels (OR 0.94, 95%CI 0.90-0.99, P < 0.01). CONCLUSION: The prevalence of vitamin D deficiency was similar to 80% in patients hospitalised with CAP. Vitamin D deficiency was also a significant predictor of increased 28-day all-cause mortality.
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