Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway

Title
Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway
Author(s)
장현욱유예이선박영나권오균박동근장영채[장영채]김철호[김철호]이은경[이은경]손종근
Keywords
NF-KAPPA-B; INULA-BRITANNICA; SIGNAL-TRANSDUCTION; NITRIC-OXIDE; KINASE; MICE; JAPONICA; LIPOPOLYSACCHARIDE; 5-LIPOXYGENASE; TRANSLOCATION
Issue Date
201405
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Citation
BIOMOLECULES & THERAPEUTICS, v.22, no.3, pp.193 - 199
Abstract
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells. To understand the biological activity of britanin, the authors investigated its effects on the generation of prostaglandin D-2 (PGD(2)), leukotriene C-4 (LTC4), and degranulation in IgE/Ag-induced bone marrow-derived mast cells (BMMCs). Britanin dose dependently inhibited degranulation and the generations of PGD(2) and LTC4 in BMMCs. Biochemical analyses of IgE/Ag-mediated signaling pathways demonstrated that britanin suppressed the phosphorylation of Syk kinase and multiple downstream signaling processes, including phospholipase C gamma 1 (PLC gamma 1)-mediated calcium influx, the activation of mitogen-activated protein kinases (MAPKs; extracellular signal-regulated kinase 1/2, c-Jun NH2-terminal kinase and p38), and the nuclear factor-kappa B (NF-kappa B) pathway. Taken together, the findings of this study suggest britanin suppresses degranulation and eicosanoid generation by inhibiting the Syk-dependent pathway and britanin might be useful for the treatment of allergic inflammatory diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/32087http://dx.doi.org/10.4062/biomolther.2014.038
ISSN
1976-9148
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약학대학 > 약학부 > Articles
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