Effect of Exercise Intensity on Unfolded Protein Response in Skeletal Muscle of Rat

Title
Effect of Exercise Intensity on Unfolded Protein Response in Skeletal Muscle of Rat
Author(s)
도경오김기훈김윤혜이성혜전만중박소영
Keywords
ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; ER STRESS; EXPRESSION; DISEASE; HUMANS; INTERVENTION; PGC-1-ALPHA; APOPTOSIS; GLUCOSE
Issue Date
201406
Publisher
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Citation
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.18, no.3, pp.211 - 216
Abstract
Endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and mitochondrial biogenesis were assessed following varying intensities of exercise -training. The animals were randomly assigned to receive either low- (LIT, n=7) or high intensity training (HIT, n=7), or were assigned to a control group (n=7). Over 5 weeks, the animals in the LIT were exercised on a treadmill with a 100 incline for 60 min at a speed of 20 m/min group, and in the HIT group at a speed of 34 m/min for 5 days a week. No statistically significant differences were found in the body weight, plasma triglyceride, and total cholesterol levels across the three groups, but fasting glucose and insulin levels were significantly lower in the exercise-trained groups. Additionally, no statistically significant differences were observed in the levels of PERK phosphorylation in skeletal muscles between the three groups. However, compared to the control and LIT groups, the level of BiP was lower in the HIT group. Compared to the control group, the levels of ATF4 in skeletal muscles and CHOP were significantly lower in the HIT group. The HIT group also showed increased PGC-1 alpha mRNA expression in comparison with the control group. Furthermore, both of the trained groups showed higher levels of mitochondrial UCP3 than the control group. In summary, we found that a 5-week high-intensity exercise training routine resulted in increased mitochondrial biogenesis and decreased ER stress and apoptotic signaling in the skeletal muscle tissue of rats.
URI
http://hdl.handle.net/YU.REPOSITORY/32033http://dx.doi.org/10.4196/kjpp.2014.18.3.211
ISSN
1226-4512
Appears in Collections:
의과대학 > 생리학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
의과대학 > 예방의학교실 > Articles
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