Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity

Title
Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity
Author(s)
이위Ya Nan Sun[Ya Nan Sun]김장훈[김장훈]Xi Tao Yan[Xi Tao Yan]김은지[김은지]양서영[양서영]김영호[김영호]
Keywords
IN-VIVO; ANTHRAQUINONES; COMPONENTS; THUNB; INFLAMMATION; GLUCOSIDES; METABOLISM; DISCOVERY; GLYCOSIDE; PRODUCTS
Issue Date
201506
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.38, no.6, pp.998 - 1004
Abstract
Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 +/- A 0.5 to 48.6 +/- A 3.1 mu M. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type.
URI
http://hdl.handle.net/YU.REPOSITORY/32031http://dx.doi.org/10.1007/s12272-014-0520-4
ISSN
0253-6269
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생명공학부 > 생명공학부 > Articles
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