Progress in Studies on Rutaecarpine. II.-Synthesis and Structure-Biological Activity Relationships

Title
Progress in Studies on Rutaecarpine. II.-Synthesis and Structure-Biological Activity Relationships
Author(s)
장영동손종근장현욱
Keywords
EVODIA-RUTAECARPA; INHIBITORY-ACTIVITY; QUINAZOLINE ALKALOIDS; LUOTONIN-A; ACETYLCHOLINESTERASE INHIBITORS; QUINAZOLINOCARBOLINE ALKALOIDS; EUODIA-RUTAECARPA; ANALOGS; DERIVATIVES; BUTYRYLCHOLINESTERASE
Issue Date
201506
Publisher
MDPI AG
Citation
MOLECULES, v.20, no.6, pp.10800 - 10821
Abstract
Rutaecarpine is a pentacyclic indolopyridoquinazolinone alkaloid found in Evodia rutaecarpa and other related herbs. It has a variety of intriguing biological properties, which continue to attract the academic and industrial interest. Studies on rutaecarpine have included isolation from new natural sources, development of new synthetic methods for its total synthesis, the discovery of new biological activities, metabolism, toxicology, and establishment of analytical methods for determining rutaecarpine content. The present review focuses on the synthesis, biological activities, and structure-activity relationships of rutaecarpine derivatives, with respect to their antiplatelet, vasodilatory, cytotoxic, and anticholinesterase activities.
URI
http://hdl.handle.net/YU.REPOSITORY/32009http://dx.doi.org/10.3390/molecules200610800
ISSN
1420-3049
Appears in Collections:
약학대학 > 약학부 > Articles
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