Impact of statin usage patterns on outcomes after percutaneous coronary intervention in acute myocardial infarction: Korea Working Group on Myocardial Infarction registry (KorMI) study

Title
Impact of statin usage patterns on outcomes after percutaneous coronary intervention in acute myocardial infarction: Korea Working Group on Myocardial Infarction registry (KorMI) study
Author(s)
박종선이상희이찬희[이찬희]김영조김기식[김기식]채성철[채성철]김효수[김효수]최동주[최동주]조명찬[조명찬]나승운[나승운]정명호[정명호]
Keywords
THERAPY; ATORVASTATIN; MORTALITY; DISCONTINUATION; PRAVASTATIN; WITHDRAWAL; ADMISSION
Issue Date
201406
Publisher
SCIENCE PRESS
Citation
JOURNAL OF GERIATRIC CARDIOLOGY, v.11, no.2, pp.93 - 99
Abstract
Background The benefit of statin use after acute ST-segment elevation myocardial infarction (STEMI) has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention (PCI). Methods This analysis of the Korea Working Group on Myocardial Infarction registry (KorMI) study included 3,584 STEMI patients (mean age, 63 +/- 13 years; male, 2,684, 74.9%) undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events (MACE: all-cause death, recurrent MI, and target lesion revascularization) were compared among patients grouped according to statin therapy timing: I, both during and after hospitalization (n = 2,653, 74%); II, only during hospitalization (n = 309, 8.6%); III, only after discharge (n = 157, 4.4%); and IV, no statin therapy (n = 465, 13%). Mean follow-up duration was 234 +/- 113 days. Results Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups III and IV had the highest MACE rates (2.3%, 3.9%, 5.1%, and 4.9% for groups I-IV, respectively, P = 0.004). After adjusting for confounders, groups II-IV had a higher MACE risk than group I [ hazard ratio (HR): 3.20, 95% confidence interval (95% CI): 1.31-7.86, P = 0.011; HR: 3.84, 95% CI: 1.47-10.02, P = 0.006; and HR: 3.17, 95% CI: 1.59-6.40, P = 0.001; respectively]. Conclusions This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical practice.
URI
http://hdl.handle.net/YU.REPOSITORY/32002http://dx.doi.org/10.3969/j.issn.1671-5411.2014.02.010
ISSN
1671-5411
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의과대학 > 내과학교실 > Articles
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