dbHiMo: a web-based epigenomics platform for histone-modifying enzymes

Title
dbHiMo: a web-based epigenomics platform for histone-modifying enzymes
Author(s)
전준현최재영[최재영]김기태[김기태]허아람[허아람]권서문[권서문]홍찬영[홍찬영]Fred O. Asiegbu[Fred O. Asiegbu]이용환[이용환]
Keywords
CHROMATIN; GENOME; YEAST; GCN5; SEQUENCE; COMPACTION; PHYLOGENY; CROSSTALK; EVOLUTION; PROTEINS
Issue Date
201506
Publisher
OXFORD UNIV PRESS
Citation
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Abstract
Over the past two decades, epigenetics has evolved into a key concept for understanding regulation of gene expression. Among many epigenetic mechanisms, covalent modifications such as acetylation and methylation of lysine residues on core histones emerged as a major mechanism in epigenetic regulation. Here, we present the database for histone-modifying enzymes (dbHiMo; http://hme.riceblast.snu.ac.kr/) aimed at facilitating functional and comparative analysis of histone-modifying enzymes (HMEs). HMEs were identified by applying a search pipeline built upon profile hidden Markov model (HMM) to proteomes. The database incorporates 11 576 HMEs identified from 603 proteomes including 483 fungal, 32 plants and 51 metazoan species. The dbHiMo provides users with web-based personalized data browsing and analysis tools, supporting comparative and evolutionary genomics. With comprehensive data entries and associated web-based tools, our database will be a valuable resource for future epigenetics/epigenomics studies.
URI
http://hdl.handle.net/YU.REPOSITORY/31973http://dx.doi.org/10.1093/database/bav052
ISSN
1758-0463
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생명공학부 > 생명공학부 > Articles
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