Organocatalyzed oxidative N-annulation for diverse and polyfunctionalized pyridines

Title
Organocatalyzed oxidative N-annulation for diverse and polyfunctionalized pyridines
Author(s)
이용록카날하리더더
Keywords
ONE-POT SYNTHESIS; HIGHLY FUNCTIONALIZED PYRIDINES; SUBSTITUTED PYRIDINES; ANXIOLYTIC ACTIVITY; CASCADE REACTIONS; DERIVATIVES; CYCLOADDITION; CONSTRUCTION; ALKALOIDS; 2,2'-BIPYRIDINE
Issue Date
201506
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.51, no.46, pp.9467 - 9470
Abstract
This paper describes a novel strategy for the synthesis of 2,3,4-trisubstituted pyridines via organocatalyzed three-component reactions. A variety of pyridine derivatives are synthesized from readily available ketones with alpha,beta-unsaturated aldehydes and ammonium acetate under a mild organocatalyst. This protocol leads to rapid N-annulation through C-C and C-N bond formation in a single operation, thereby avoiding the preparation of essential functional groups, such as oximes, imines, or azides. The synthesized compounds are used for the evaluation of antibacterial activities and as fluorescence sensors for Cu2+ ions.
URI
http://hdl.handle.net/YU.REPOSITORY/31962http://dx.doi.org/10.1039/c5cc01807b
ISSN
1359-7345
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공과대학 > 화학공학부 > Articles
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