Validation of the Generalized Anxiety Disorder-7 in people with epilepsy: A MEPSY study

Title
Validation of the Generalized Anxiety Disorder-7 in people with epilepsy: A MEPSY study
Author(s)
이세진Jong-Geun Seo[Jong-Geun Seo]YongWon Cho[YongWon Cho]Jang-Joon Lee[Jang-Joon Lee]Ji-Eun Kim[Ji-Eun Kim]Hye-Jin Moon[Hye-Jin Moon]Sung-Pa Park[Sung-Pa Park]
Keywords
QUALITY-OF-LIFE; DEPRESSION INVENTORY; NDDI-E; HOSPITAL ANXIETY; PSYCHIATRIC COMORBIDITY; AFFECTIVE SYMPTOMS; VERSION; POPULATION; COMMUNITY; SCALE
Issue Date
201406
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
EPILEPSY & BEHAVIOR, v.35, pp.59 - 63
Abstract
The Generalized Anxiety Disorder-7 (GAD-7) is a valuable instrument to screen for anxiety in primary care patients. However, it has not been validated in people with epilepsy (PWE). Therefore, we validated the GAD-7 and examined its differential effect from adverse effects of antiepileptic drugs (AEDs) on the detection of anxiety in Korean PWE. Eligible patients who visited outpatient clinics in 4 tertiary care hospitals and 1 secondary care hospital underwent several instruments including the Mini International Neuropsychiatric Interview-Plus Version 5.0.0 (MINI-Plus 5.0.0), the Korean version of the Neurological Disorders Depression Inventory for Epilepsy (K-NDDI-E), the Korean version of the Liverpool Adverse Event Profile (K-LAEP), and the Quality of Life in Epilepsy-10 (QOLIE-10). Two hundred forty-three patients were enrolled in the study, and 51 (21.0%) patients had GAD by the MINI-Plus 5.0.0. Cronbach's a coefficient for the GAD-7 was 0.924. At a cutoff score of 6, the GAD-7 had a sensitivity of 92.2%, a specificity of 89.1%, a positive predictive value of 69.1%, and a negative predictive value of 97.7%. The GAD-7 score was well correlated with the K-NDDI-E score, the K-LAEP score, and the QOLIE-10 overall and subscale scores. The impact of adverse effects of AEDs on the GAD-7 was less than that on the K-NDDI-E. In conclusion, the GAD-7 is a reliable and valid screening tool for detecting GAD in PWE. (C) 2014 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31944http://dx.doi.org/10.1016/j.yebeh.2014.04.005
ISSN
1525-5050
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의과대학 > 신경과학교실 > Articles
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