Inhibitory activities of ethanol extracts from Saururus chinensis L. against stress-induced hemorrhagic gastritis

Title
Inhibitory activities of ethanol extracts from Saururus chinensis L. against stress-induced hemorrhagic gastritis
Author(s)
박소영조영제[조영제]
Keywords
Saururus chinensis
Issue Date
201506
Citation
Journal of the Korean Society of Food Science and Nutrition, v.44, no.6, pp.800 - 808
Abstract
In this study, gastritis inhibitory substance was ethanol-extracted from Saururus chinensis in order to examine the effect as a part of natural bioactive substance research. In an oral administration experiment, S. chinensis was administered at doses of 0.25 g/kg B.W. to 2 g/kg B.W., resulting in stabilization at 1.5 g/kg B.W. and an LD50 of 1.81 g/kg B.W. In a chronic toxicity experiment, 0.5 g/kg B.W. of S. chinensis was administered for 13 weeks, but toxicity was not observed. S. chinensis ethanol-extracts were administered at a concentration of 250 or 500 mg/kg B.W. before induction of gastritis. Gastrorrhagia, stomach edema, cytokine production, and cell damage were reduced in a concentration-dependent manner. Therefore, S. chinensis ethanol extracts inhibit cell damage by stress-induced hemorrhagic gastritis in a concentration-dependent manner via inhibition of cytokine expression. ? 2015, Korean Society of Food Science and Nutrition. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31933http://dx.doi.org/10.3746/jkfn.2015.44.6.800
ISSN
1226-3311
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의과대학 > 생리학교실 > Articles
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