Anmindenols A and B, Inducible Nitric Oxide Synthase Inhibitors from a Marine-Derived Streptomyces sp.

Title
Anmindenols A and B, Inducible Nitric Oxide Synthase Inhibitors from a Marine-Derived Streptomyces sp.
Author(s)
최혁재이지혜[이지혜]김희영[김희영]이태구[이태구]양인호[양인호]원동환[원동환]남상집[남상집]강헌중[강헌중]
Keywords
SECONDARY METABOLITES; SESQUITERPENES; BACTERIAL; BIOSYNTHESIS; DIVERSITY
Issue Date
201406
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.77, no.6, pp.1528 - 1531
Abstract
Anmindenols A (1) and B (2), inhibitors of inducible nitric oxide synthase (iNOS), were isolated from a marine-derived bacterium Streptomyces sp. Their chemical structures were elucidated by interpreting various spectroscopic data, including IR, MS, and NMR. Anmindenols A and B are sesquiterpenoids possessing an indene moiety with five- and six membered rings derived from isoprenyl units. The absolute configuration of C-4 in anmindenol B was determined by electronic circular dichroism (ECD) of a dimolybdenum complex. Anmindenols A (1) and B (2) inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells with IC50 values of 23 and 19 mu M, respectively.
URI
http://hdl.handle.net/YU.REPOSITORY/31906http://dx.doi.org/10.1021/np500285a
ISSN
0163-3864
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약학대학 > 약학부 > Articles
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