Photoassisted One-Step Aerosol Fabrication of Zwitterionic Chitosan Nanoparticles

Title
Photoassisted One-Step Aerosol Fabrication of Zwitterionic Chitosan Nanoparticles
Author(s)
변정훈Aditya Kulkarni[Aditya Kulkarni]김희권[김희권]David H. Thompson[David H. Thompson]Jeffrey T. Roberts[Jeffrey T. Roberts]
Keywords
IN-VITRO; UV-IRRADIATION; GENE DELIVERY; DRUG; DERIVATIVES; VIVO; ABSORPTION; CONJUGATE; RELEASE; CARRIER
Issue Date
201406
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.15, no.6, pp.2320 - 2325
Abstract
Zwitterionic chitosan nanoparticles (ZCNPs) were conveniently obtained by a one-step aerosol method, and their potential for the production of biocompatible materials was investigated. A low-molecular-weight chitosan was conjugated with succinic anhydride to produce zwitterionic chitosan (ZC). Collisonatomized ZC droplets were simultaneously UV-irradiated and dried in a tube furnace in a one-step aerosol process to produce particles. The observed cytotoxicities of ZCNPs (85 +/- 3.9% cell viability) were similar to unmodified chitosan nanoparticles (CNPs, 88 +/- 6.6%) and UV-irradiated ZCNPs (83 +/- 3.3%). The aerosol process described in this work allowed facile production and modification of CNPs, which could then be employed for biomedical purposes.
URI
http://hdl.handle.net/YU.REPOSITORY/31899http://dx.doi.org/10.1021/bm5005417
ISSN
1525-7797
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공과대학 > 기계공학부 > Articles
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