Acute and 4-Week Repeated-Dose Oral Toxicity Studies of Cirsium setidens in Rats

Title
Acute and 4-Week Repeated-Dose Oral Toxicity Studies of Cirsium setidens in Rats
Author(s)
방우석Lee, Jone-Seok[Lee, Jone-Seok]Kim. Young-Hyun[Kim. Young-Hyun]kim, Dan-Bi[kim, Dan-Bi]Lee, Ok-Hwan[Lee, Ok-Hwan]
Keywords
ANTIOXIDANT ACTIVITY; KOREAN THISTLES; HEALTH-BENEFITS; JAPONICUM DC; EXTRACT; MICE; PECTOLINARIN; PROFILES; FLAVONE; INJURY
Issue Date
201406
Publisher
MDPI AG
Citation
MOLECULES, v.19, no.6, pp.7138 - 7151
Abstract
Cirsium setidens is a wild perennial plant species found in Korea that may have anti-oxidative, anti-adipogenic, and hepatoprotective activities. However, details of the toxicology of C. setidens remain unknown. This study was performed to evaluate the toxicological effects of an acute administration and 4-week repeated dosing of a C. setidens extract in Sprague-Dawley rats to ensure the safe use of this extract. C. setidens (1250, 2500, and 5000 mg/kg body weight/day) did not induce significant toxicological changes in groups matched by gender with respect to mortality, clinical signs, body weight, urinalysis, ophthalmoscopy, necropsy findings, hematology, and histopathology. Therefore, this study demonstrates that acute administration and 4-week repeated dosing of C. setidens extract orally using this administration protocol is safe.
URI
http://hdl.handle.net/YU.REPOSITORY/31895http://dx.doi.org/10.3390/molecules19067138
ISSN
1420-3049
Appears in Collections:
생활과학대학 > 식품영양학과 > Articles
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